Pomalidomide-PEG1-CO2H - CAS 2139348-60-8

Pomalidomide-PEG1-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

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Molecular Formula
C18H19N3O7
Molecular Weight
389.36

Pomalidomide-PEG1-CO2H

    • Specification
      • Purity
        ≥98%
        Solubility
        Soluble in DMSO
        Appearance
        Solid
        Shelf Life
        2 years
        Storage
        Store at 2-8°C, stored under nitrogen, away from moisture
        IUPAC Name
        3-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]propanoic acid
        Synonyms
        Thalidomide-NH-PEG1-COOH; Pomalidomide-PEG1-C2-COOH; Pomalidomide-PEG1-COOH; Pomalidomide-PEG1-CH2CH2COOH; 3-(2-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)propanoic acid; Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-; 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid
    • Properties
      • Boiling Point
        726.2±60.0°C at 760 mmHg
        Density
        1.5±0.1 g/cm3
        InChI Key
        GXCGXOBFROXMLV-UHFFFAOYSA-N
        InChI
        InChI=1S/C18H19N3O7/c22-13-5-4-12(16(25)20-13)21-17(26)10-2-1-3-11(15(10)18(21)27)19-7-9-28-8-6-14(23)24/h1-3,12,19H,4-9H2,(H,23,24)(H,20,22,25)
        Canonical SMILES
        C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCC(=O)O
Bio Calculators
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L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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