A 410099.1 amide-PEG2-amine-Boc - CAS 2415256-16-3

A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 2 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand.

* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

Molecular Formula
C₃₈H₆₀N₆O₈
Molecular Weight
728.92

A 410099.1 amide-PEG2-amine-Boc

    • Specification
      • Storage
        Store at -20°C
        Shipping
        Room temperature in continental US; may vary elsewhere.
    • Properties
      • InChI Key
        LEBUBVVDWZLBBX-SHHSPICZSA-N
        Canonical SMILES
        CN([C@@H](C)C(N[C@@H](C1CCCCC1)C(N2C[C@H](C[C@H]2C(N[C@@H]3CCCC4=CC=CC=C34)=O)NC(COCCOCCN)=O)=O)=O)C(OC(C)(C)C)=O
        Pub Chem ID
        146018938
    • Reference Reading
      • 1. [Hypoglycemic sulfonylurea metabolites: clinical interest. Experiences with glibenclamide in the rat
        H Samimi, L Loutan, L Balant, M Tillolès, J Fabre Schweiz Med Wochenschr. 1977 Sep 17;107(37):1291-6.
        Glibenclamide, a hypoglycemic sulfonylurea, is extensively metabolized by the body and eliminated primarily in the form of its hydroxylated derivatives. The major metabolite, 4-trans-hydroxy-glibenclamide, is usually cleared rapidly from the bloodstream, but in certain pathological states (e.g. renal failure) blood levels of this product may increase. A protocol therefore was designed to test the hypoglycemic potency of this important metabolite in rats. Various quantities were injected intraperitoneally, and alterations in blood glucose concentrations were measured during a 5-hour period and compared to those in animals similarly treated with glibenclamide and in saline-injected controls. Using the dose capable of decreasing blood glucose levels by 30% (ED30) as a comparative index, it was observed that the metabolic has a marked hypoglycemic activity; though 6--7 times less potent than the parent drug, 4-trans-hydroxy-glibenclamide is nevertheless more potent than tolbutamide. Thus, while the glibenclamide metabolite probably has little influence on blood glucose when its clearance is normal, this product may exert marked effects if allowed to accumulate in the blood, as for example in renal failure. Finally, the role of such sulfonylurea metabolites should be taken into account when attempting to explain the occasional excessive and sustained hypoglycemia which occurs in some diabetic patients treated with these drugs.
Bio Calculators
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g
Related Products
BOC Sciences Support

Please contact us with any specific requirements and we will get back to you as soon as possible.


  • Verification code

We invite you to contact us at or through our contact form above for more information about our services and products.

USA
  • International:
  • US & Canada (Toll free):
  • Email:
  • Fax:
UK
  • Email:
Inquiry Basket