Thalidomide-linker 3 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand thalidomide and an alkyl chain linker. It has been used as a degrader building block in PROTAC for targeted protein degradation.
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| Molecular Formula | C19H22N4O6.HCl |
| Molecular Weight | 438.86 |
| Purity | ≥98% |
| Synonyms | N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride |
| Storage | -20°C |
| Shelf Life | 2 years |
| InChI Key | UZDTXDUTMCCMDO-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H22N4O6.ClH/c20-8-1-2-9-21-15(25)10-29-13-5-3-4-11-16(13)19(28)23(18(11)27)12-6-7-14(24)22-17(12)26;/h3-5,12H,1-2,6-10,20H2,(H,21,25)(H,22,24,26);1H |
| Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCN.Cl |
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
