Thalidomide-linker 4 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand thalidomide and an alkyl chain linker. It has been used as a degrader building block in PROTAC for targeted protein degradation.
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| Molecular Formula | C19H23N3O5.HCl |
| Molecular Weight | 409.86 |
| Purity | ≥98% |
| Synonyms | 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Storage | -20°C |
| Shelf Life | 2 years |
| InChI Key | HYHUBACBCPALHK-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H23N3O5.ClH/c20-10-3-1-2-4-11-27-14-7-5-6-12-16(14)19(26)22(18(12)25)13-8-9-15(23)21-17(13)24;/h5-7,13H,1-4,8-11,20H2,(H,21,23,24);1H |
| Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCN.Cl |
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
