Thalidomide-linker 4 - CAS 2245697-88-3

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Thalidomide-linker 4 is a crosslinker−E3 ligase ligand conjugate composed of a cereblon-recuiting ligand thalidomide and an alkyl chain linker. It has been used as a degrader building block in PROTAC for targeted protein degradation.

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Molecular Formula C19H23N3O5.HCl
Molecular Weight 409.86

Thalidomide-linker 4

Purity ≥98%
Synonyms 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Storage -20°C
Shelf Life 2 years
InChI Key HYHUBACBCPALHK-UHFFFAOYSA-N
InChI InChI=1S/C19H23N3O5.ClH/c20-10-3-1-2-4-11-27-14-7-5-6-12-16(14)19(26)22(18(12)25)13-8-9-15(23)21-17(13)24;/h5-7,13H,1-4,8-11,20H2,(H,21,23,24);1H
Canonical SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCN.Cl

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
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