Degradation Ability Assay


* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

The goal of Proteolysis Targeting Chimeric (PROTAC) technology is to degrade the target protein, so in some related studies, the degradation ability of the target proteins needs to be measured. With many years of technical experience and professional technical team, BOC Sciences has established an advanced one-stop PROTAC service platform to provide multiple technical services related to PROTAC technology, including degradation ability assay. Our rich experience and professional technical capabilities can help customers achieve degradation analysis of target proteins in a shorter period.

Introduction

PROTAC technology is a potential technology in the field of drug design. PROTAC compounds have two specific ligands that can interact with E3 ubiquitin ligase and recruit the target proteins. It can trigger ubiquitination of the target protein through the ubiquitin proteasomal system (UPS), and finally induce the protein of interest to be targeted for degradation by proteasome. Therefore, degradation ability analysis of PROTAC technology can be carried out by measuring the degradation rate of the target protein directly, or by analyzing the ubiquitination of the target protein. Various parameters in the development process of PROTAC technology will ultimately affect the degradation efficiency of the target protein, such as the stability of the PROTAC compound. Therefore, the study of protein degradation ability is also an important field in the research of PROTAC technology. Analysis of degradation ability can help researchers to analyze the potency of PROTAC in promoting the degradation of targeted proteins in detail, and is conducive to the development and optimization of PROTAC technology.

Our Services for Degradation Ability Assay (include but not limited to the following):

Our Advantages

Workflow of Degradation Ability Assay

Degradation Ability Assay

Reference:

  1. Eldeeb, M. A.; et al. A molecular toolbox for studying protein degradation in mammalian cells. Journal of neurochemistry. 2019, 151(4): 520-533.

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