PROTAC In Vivo Animal Model


* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

BOC Sciences has established an advanced one-stop PROTAC service platform to provide R&D outsourcing services to provide customers with high-quality data and rapid research cycle of drug preclinical safety evaluation services. We can help customers shorten the trial time and reduce the cost of new drug research and development by controlling costs and efficient services.

Introduction

Drug safety is not only an important factor leading to the failure of drug research and development, but also the main reason for the delisting of drugs. Traditionally, the toxicity test and safety evaluation of drugs are generally completed in preclinical animal trials. Once a serious toxic reaction of the drug is found, which leads to the failure of research and development, it will cause huge economic losses. PROTAC is a small molecule composed of target protein ligand, E3 ligase ligand and connector. It may be a potential drug because it can degrade disease-causing proteins. For the process of drug discovery and development, in vivo animal experiments are very important and decisive for clinical trials of candidate PROTAC. In addition, the results of animal experiments in vivo can be used to guide the pilot optimization of PROTAC to ensure low toxicity and better ADME performance.

Below is a list of our available PROTAC In Vivo Evaluation Service (include but not limited to the following):

Our Advantages

Workflow of PROTAC In Vivo Animal Model

PROTAC In Vivo Animal Model

References:

  1. Testa, A., Hughes, S. J., Lucas, X., Wright, J. E., & Ciulli, A. (2019). Structure‐Based Design of a Macrocyclic PROTAC. Angewandte Chemie International Edition.
  2. Carmony, K. C., & Kim, K. B. (2012). PROTAC-induced proteolytic targeting. In Ubiquitin Family Modifiers and the Proteasome (pp. 627-638). Humana Press.

Online Inquiry


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USA

  • International: 1-631-504-6093
  • US & Canada (Toll free): 1-844-BOC(262)-0123
  • 45-16 Ramsey Road, Shirley, NY 11967, USA
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  • Fax: 1-631-614-7828

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