PROTAC Activity Assay


* Please be kindly noted that our services and products can only be used for research to organizations or companies and not intended for any clinical or individuals.

As a leading service provider in the field of drug discovery and research, BOC Sciences has established an advanced one-stop Proteolysis Targeting Chimeric (PROTAC) service platform. We offer technical services for PROTAC activity assay. Our expert team has rich experience and professional technical knowledge about PROTAC activity assay, and can carry out the activity detection according to the specific needs of different customers.

Introduction

PROTAC is composed of 3 independent parts, and each part can be replaced or adjusted individually, so that there is a difference in activity between different PROTAC compounds. For example, the change of linker length has a certain effect on the activity of PROTAC to degrade the estrogen receptor. In addition, the peptide length of E3 ligase recognition motif and the binding site of the linker also changes the activity of PROTAC. The activity of PROTAC directly affects its potency and the degradation of the target protein, so it is necessary to perform PROTAC activity assay during its development and screening process.

PROTAC Activity Assay

Our Services for PROTAC Activity Assay (include but not limited to the following):

Our Advantages

Workflow of PROTAC Activity Assay

PROTAC Activity Assay

References:

  1. Cyrus, K.; et al. Impact of linker length on the activity of PROTACs. Molecular BioSystems. 2011, 7(2): 359-64.
  2. Toure, M.; Crews, C. M. Small-molecule PROTACS: new approaches to protein degradation. Angewandte Chemie International Edition. 2016, 55(6): 1966-1973.
  3. Daniels, D.L.; et al. Monitoring and deciphering protein degradation pathways inside cells. Drug Discovery Today: Technologies. 2019, 31: 61-68.

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